Sixteen[3,6(4-substituedaryl)1-(1,2hydrazino-2-oxoethyl) – 2 – oxo-1,2,3,4tetrahydropyrimidine-5-yl]propionic acid derivatives have been synthesized in a four-step reaction. In the first step benzene or substituted benzene react with glutaric anhydride in presence of aluminium trichloride (Friedel Craft reaction) to obtain 5-(substituted phenyl)-5-oxo pentanoic acid. Second step involves synthesis of [4, 6 (4-substituted aryl)-2-oxo-1, 2, 3, 4- tetrahydropyrimine-5 yl propionic acid by reaction between 5-(substituted phenyl)-5-oxo pentanoic acid, urea and substituted aldehydes (Biginelli reaction).Third step involves reaction of [4, 6 (4-substituted aryl)-2-oxo-1, 2, 3, 4- tetrahydropyrimine-5yl propionic acid was dissolved in a solution prepared by reacting Na (0.1mol) with 200ml of absolute ethanol and then solution is refluxed with ethyl chloroacetate to produce 3-[4-chloro-6-(4-chlorophenyl)-1-(2-ethoxy-2-oxoethyl)-2-oxo-1,2-dihydropyrimidin-5-yl]propanoic acid. In forth step Compound (3) was treated with hydrazine hydrate to form[3, 6 (4- substituted aryl)1-(1,2 hydrazino-2-oxoethyl)-2oxo-1,2,3,4-tetrahydropyrimidine-5-yl] propionic acid derivatives. Their structures are confirmed by IR, 1H NMR. TLC of synthesized compounds performed in chloroform: ethanol (3:1) solvent system. The anti-inflammatory activity of all compounds has been recorded on the basis of reference standard Indomethacin. All the compounds showed tendency to cause a fall in oedema and showed anti-inflammatory activity. Anti-inflammatory activity of all compounds was taken by Carrageenan induced rat paw oedema on albino rats.
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